- Peter Agre, biologist who received 2003 Nobel Prize in Chemistry (Eagle Scout, Class of 1964)
- Buzz Aldrin, second man to walk on the moon
- Dr. James Andrews, surgeon who has treated many high-profile athletes, including Drew Brees and Charles Barkley (Eagle Scout)
- Neil Armstrong, astronaut and first man to walk on the moon (Eagle Scout, Class of 1947)
- Lee Berger, National Geographic explorer and paleoanthropologist (Eagle Scout, Class of 1983)
- Guion Bluford, first African-American in space (Eagle Scout)
- Thomas Cech, chemist who received 1989 Nobel Prize in Chemistry (Eagle Scout, Class of 1962)
- Roger Chaffee, astronaut who was killed in the Apollo 1 mission (Eagle Scout, Class of 1951)
- Dr. Kenneth H. Cooper, father of modern aerobics (Eagle Scout, Class of 1946)
- Charles Duke, astronaut and 10th man to walk on the moon (Eagle Scout, Class of 1946)
- Philo T. Farnsworth, inventor of the modern television (Eagle Scout, Class of 1932)
- Steve Fossett, record-setting aviator (Eagle Scout, Class of 1957)
- Jim Lovell, astronaut who was commander of Apollo 13 mission (Eagle Scout, Class of 1943)
- William Moerner, physicist who received 2014 Nobel Prize in Chemistry (Eagle Scout, Class of 1967)
- Ellison Onizuka, astronaut who died in the Space Shuttle Challenger explosion (Eagle Scout, Class of 1964)
- Gitanjali Rao, inventor, STEM Scout and the first ever Time Kid of the Year in 2020
- Paul Siple, Antarctic explorer who coined the term “wind chill” (Eagle Scout, Class of 1924)
- E. O. Wilson, researcher, two-time Pulitzer Prize winner and the world’s top ant expert (Eagle Scout, Class of 1944)